Asisat Oshoala is set to be out of action for two months and has been ruled out of the Nigeria camp later this month in Abuja after picking up a hamstring injury.
The Nigeria international was forced off in the second half of Barcelona's 4-0 Champions League group stage win over Hoffenheim on Wednesday and assessments have revealed she will not be fit to join the Super Falcons camp.
According to the club's statement on Friday, the Nigerian suffered a "rupture of the posterior cruciate ligament of the right knee and will be about two months off".
The news will come as a blow to Randy Waldrum, who had initially included the Super Falcons captain for selection ahead of the international break from November 22-30 in build up to February's showdown to Cote d'Ivoire.
The Barcelona goal machine has been in grand form in the 2021-22 campaign - scoring 11 times in her last nine fixtures for the Spaniards in all competition.
Despite her good form at club level, the 28-year-old has been unable to re-enact her Barcelona scoring form for the nine-time African champions, with her last Nigeria goals coming against Equatorial Guinea in February.
Against the Nzalang Nacional, Oshoala found the net on four occasions in the Super Falcons' 9-0 in a Turkish Women's Cup outing but she has now gone on international drought to six games, including against Ghana in October's Africa Women's Cup of Nations qualification doubleheader .
Expectedly, Oshoala will shoulder the Super Falcons look to square up against Niger Republic or Cote d'Ivoire in the second round next Feburary, but the latest development around the striker leaves Waldrum with huge concerns.
Morocco 2022 will be used to decide Africa's qualifiers for the 2023 Fifa Women's World Cup and Nigeria will hope Oshoala will recover in time for the doubleheader with the Elephants next Feburary.